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INDICATION AND IMPORTANT SAFETY INFORMATION

Indication CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off. CONTRAVE should be used with a reduced-calorie diet and increased physical activity. It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke. It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products. CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation). Important Safety Information CONTRAVE can cause serious side effects including: Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes. Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping. CONTRAVE is not approved for use in children under the age of 18. Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE. Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. CONTRAVE may cause serious side effects, including: <ul> <li>Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.</li> <li>Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.</li> <li>Get emergency medical help right away if you take opioids and you: <ul style="margin-left: 40px"> 	<li>have trouble breathing</li> 	<li>become very drowsy with slowed breathing</li> 	<li>have slow, shallow breathing</li> 	<li>feel faint, very dizzy, confused, or have unusual symptoms</li> </ul></li> <li>Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.</li> <li>Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.</li> <li>Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.</li> <li>Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.</li> <li>Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.</li> <li>Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.</li> <li>Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.</li> </ul> The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="http://www.fda.gov/medwatch" target="_new">www.fda.gov/medwatch</a> or call <a href="tel:+18003321088">1-800-FDA-1088.</a> Please see <a href="https://contrave.com/contrave-pi/" target="_new">Full Prescribing Information</a>, including <a href="https://contrave.com/wp-content/uploads/2020/12/CONTRAVE_Med_Guide.pdf" target="_new">Medication Guide</a>, for CONTRAVE.

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Complete a quick medical questionnaire (in less than 5 minutes), and then you'll have a brief phone or video consult with one of our board-certified physcians. If your prescription is approved, CONTRAVE will be shipped out that day or the next.

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What is CONTRAVE? CONTRAVE is a prescription weight-loss medicine that may help adults with obesity, or some adults who are overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. CONTRAVE should be used with a reduced-calorie diet and increased physical activity. It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke. CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation). IMPORTANT SAFETY INFORMATION CONTRAVE can cause serious side effects including: Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment. While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes. Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping. CONTRAVE is not approved for use in children under the age of 18. Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE. Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. CONTRAVE may cause serious side effects, including: <ul> <li>Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.</li> <li>Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.</li> Get emergency medical help right away if you take opioids and you: <ul style="margin-left: 40px"> 	 <li>have trouble breathing</li> 	 <li>become very drowsy with slowed breathing</li> 	 <li>have slow, shallow breathing</li> 	 <li>feel faint, very dizzy, confused, or have unusual symptoms</li> </ul> <li>Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.</li> <li>Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.</li> <li>Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.</li> <li>Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.</li> <li>Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.</li> <li>Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.</li> <li>Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.</li> </ul> The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="http://www.fda.gov/medwatch" target="_new" style="color: blue; text-decoration: underline;">www.fda.gov/medwatch</a> or call <a href="tel:+18003321088" style="color: blue; text-decoration: underline;">1-800-FDA-1088.</a> Please see <a href="https://curraxpharma.com/PI/Contrave-label-current.pdf" target="_new" style="color: blue; text-decoration: underline;">Full Prescribing Information</a>, including <a href="https://www.curraxpharma.com/MG/contrave-label-current.pdf/" target="_new" style="color: blue; text-decoration: underline;">Medication Guide</a>, for CONTRAVE.

Complete a quick medical questionnaire (in less than 5 minutes), and then you&#8217;ll have a brief phone or video consult with one of our board-certified physicians. If your prescription is approved, CONTRAVE will be shipped out that day or the next.

Get CONTRAVE delivered directly to your door with free home delivery!

*Based on the number of prescription fills for brand name oral weight-loss drugs in the IQVIA database, October 2025.

CONTRAVE The #1 Prescribed Non-GLP-1 Oral Weight-Loss Brand*

*Other areas of the brain may be involved. The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood.

CONTRAVE is believed to target two areas of the brain - your hunger center and your reward system - to reduce hunger and help control cravings.*

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(naltrexone HCI/bupropion HCl)Start your journey now! Complete a short medical questionnaire and a telehealth consultation with a board-certified healthcare professional.

CONTRAVE is a prescription weight-loss medicine that may help adults with obesity, or some adults who are overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. CONTRAVE should be used with a reduced-calorie diet and increased physical activity.

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If you receive your prescription package and it appears compromised, damaged, or tampered with, do not use the medication. Please contact us immediately at 855-289-3552 to report any concerns. We are committed to ensuring the safety and integrity of your medications.

Drospirenone and Estetrol tablets 3 mg/14.2 mg

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Indication CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight)...

CONTRAVE $99/month $45 physician consultation fee on all new orders. Full refund if not approved. *Based on the number of prescription fills for brand name oral weight-loss drugs in the IQVIA database, October 2025.

CONTRAVE The #1 Prescribed Non-GLP-1 Oral Weight-Loss Brand*

Complete a short medical questionnaire to help the healthcare provider better understand your medical history to help them understand if CONTRAVE could be right for you.

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See if CONTRAVE is right for you.

Get your prescription approved via a quick and affordable virtual appointment.

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Connect with a healthcare provider.

If you are prescribed CONTRAVE, it will be sent directly to you.

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Receive your medication

Complete a quick medical questionnaire (in less than 5 minutes), and then you'll have a brief phone or video consult with one of our board-certified physicians. If your prescription is approved, CONTRAVE will be shipped out that day or the next.

Feel free to contact us. <a href="mailto:service@GetContrave.com">service@GetContrave.com</a> Phone: (855) 288-8428

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CONTRAVE helps you reduce hunger and control cravings to lose weight and keep it off.††The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood. Please visit <a href="https://www.contrave.com/" target="_blank" style="color:#219ee0";>CONTRAVE.com</a> if you need more information about CONTRAVE.

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Need Help With Your Prior Authorization for Contrave®? If your provider didn’t submit the Prior Authorization paperwork to your insurance, our licensed healthcare team can help! Request a prior authorization review today to improve your chances of getting your prescription covered and your out of pocket cost for CONTRAVE® lowered.

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Do you ever feel like you’re trapped in an endless cycle of trying to lose weight? You want a slimmer, healthier you, but you need help fighting those cravings? If so, we can help. CONTRAVE is an FDA-approved weight-loss medication that may help adults who are overweight or struggle with obesity lose weight and keep it off.

Lose weight. Gain confidence.

Across three 56-week studies, patients taking CONTRAVE lost approximately 2-4x more weight on average than with diet and exercise alone. 46% of patients on CONTRAVE lost 5% or more body weight (vs 23% of patients on placebo).

Lose 2-4x more weight on average than with diet and exercise alone.

CONTRAVE is believed to work on two important areas of the brain—your hunger center and your reward system—to reduce hunger and help control cravings. Other areas of the brain may be involved. Talk to one of our U.S. licensed physicians and started with CONTRAVE today!

Reduce hunger and control cravings to lose weight and keep it off.

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Complete a short medical questionnaire and a telehealth consultation with a board-certified healthcare professional.

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CONTRAVE® (naltrexone HCI/bupropion HCl) is a prescription weight-loss medicine that may help adults with obesity (BMI greater than or equal to 30 kg/m2), or who are overweight (BMI greater than or equal to 27 kg/m2) with at least one weight-related medical condition, lose weight and keep the weight off. CONTRAVE® should be used along with diet and exercise.